“What response on my part will bring this conversation to a speedy conclusion?”
                                                                      Sheldon, The Big Bang Theory

The number of times that I have had this thought at work is frightening...
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"Sleep is a symptom of caffeine deprivation."

...suddenly the day makes much more sense than it did...

“It came down to this. What you see depends on what you look for. You can enjoy the positives, or seek out the negatives. It’s your choice.”

Andrew Grant

I rather like this one, it wouldn't be a bad personal moto...

"Either we have all the clues & we're idiots, or we don't have all the clues."  House

Personally, i've always figured we didn't have a clue to begin with, (young idiots that we are) but for some people the first part is definitly more appropriate.